Name
Title | ||
|---|---|---|
A Fluid-Cell Interaction and Adhesion Algorithm for Tissue Coating of Cardiovascular Implants |
Abstract | ||
|---|---|---|
In this manuscript we develop a fluid-cell interaction and adhesion algorithm applied to modeling the cell coating of artificial surfaces of cardiovascular implants for improved biocompatibility. The fluid-cell interaction and adhesion algorithm proposed in this manuscript is a multiscale model that captures the process of cell adhesion which occurs at a scale of a few nanometers and couples it with fluid-cell interaction which occurs at a scale of a few hundred microns. Cells are assumed rigid and neutrally buoyant. Cell adhesion is modeled using a kinetics-based dynamic adhesion algorithm. Fluid-cell interaction is modeled using the fictitious domain method with distributed Lagrange multipliers. The coupling between the two is achieved through a time-splitting scheme. Novel results regarding the influence of certain fluid dynamic parameters and adhesion parameters on the generation of a stable and strong tissue coating of artificial surfaces are presented. The modular nature of this algorithm makes it easily applicable to a large class of problems involving the processes of cell adhesion and fluid-cell interaction. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1137/080733188 | MULTISCALE MODELING & SIMULATION |
Keywords | Field | DocType |
cell adhesion,fluid-particle interaction,cardiovascular implants,tissue coating,mathematical modeling,Navier-Stokes equations | Biocompatibility,Coupling,Micrometre,Coating,Fictitious domain method,Algorithm,Adhesion,Cell adhesion,Mathematics,Navier–Stokes equations | Journal |
Volume | Issue | ISSN |
7 | 4 | 1540-3459 |
Citations | PageRank | References |
2 | 0.42 | 1 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jian Hao | 1 | 2 | 0.42 |
| Tsorng-Whay Pan | 2 | 8 | 3.00 |
| Suncica Canic | 3 | 72 | 15.73 |
| Roland Glowinski | 4 | 188 | 50.44 |
| Doreen Rosenstrauch | 5 | 12 | 1.76 |