Name
Abstract | ||
|---|---|---|
Based upon previous reports of alterations in white matter integrity and gray matter density in smokers, we examined these markers in a large, well-matched sample of smokers and non-smokers. We further investigated the effect of heavy cigarette exposure by using pack-years and the effects of two relatively stable, highly heritable traits in smokers (Fagerström Test of Nicotine Dependence (FTND), a measure of severity of nicotine dependence and Toronto Alexithymia Scale (TAS-20), a stable personality trait related to smoking). Forty-eight nicotine-dependent subjects and 48 matched controls were included in the analyses, with smokers also subdivided into high/low dependence and high/low pack-years smokers. White matter integrity (fractional anisotropy (FA)) and gray matter density (voxel-based morphometry (VBM)) were measured and compared across groups. Gray matter density was lower in left prefrontal cortex (PFC) in high pack-years smokers and was inversely related to pack-years. In contrast, left insular cortex gray matter density was higher in smokers and associated with TAS-20 total score and with difficulty-identifying-feelings factor. Further, the most highly dependent smokers showed lower prefrontal FA, which was negatively correlated with FTND. There was no correlation between pack-years and FTND in our smoker population. These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray matter and PFC white matter appear to reflect stable and heritable differences between smokers and non-smokers. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1016/j.neuroimage.2010.08.008 | NeuroImage |
Keywords | DocType | Volume |
smoke,voxel based morphometry,magnetic resonance imaging,fractional anisotropy,emotions,thinking | Journal | 54 |
Issue | ISSN | Citations |
1 | 1053-8119 | 5 |
PageRank | References | Authors |
0.53 | 5 | 6 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Xiaochu Zhang | 1 | 17 | 5.79 |
| Betty Jo Salmeron | 2 | 23 | 4.00 |
| Thomas J Ross | 3 | 98 | 10.55 |
| Xiujuan Geng | 4 | 162 | 14.34 |
| Yihong Yang | 5 | 218 | 21.67 |
| Elliot A Stein | 6 | 283 | 38.64 |