Name
Abstract | ||
|---|---|---|
For several decades, androgen suppression has been the principal modality for treatment of advanced prostate cancer. Although
the androgen deprivation is initially effective, most patients experience a relapse within several years due to the proliferation
of so-called androgen-independent tumor cells. Bruchovsky et al. suggested in animal models that intermittent androgen suppression
(IAS) can prolong the time to relapse when compared with continuous androgen suppression (CAS). Therefore, IAS has been expected
to enhance clinical efficacy in conjunction with reduction in adverse effects and improvement in quality of life of patients
during off-treatment periods. This paper presents a mathematical model that describes the growth of a prostate tumor under
IAS therapy based on monitoring of the serum prostate-specific antigen (PSA). By treating the cancer tumor as a mixed assembly
of androgen-dependent and androgen-independent cells, we investigate the difference between CAS and IAS with respect to factors
affecting an androgen-independent relapse. Numerical and bifurcation analyses show how the tumor growth and the relapse time
are influenced by the net growth rate of the androgen-independent cells, a protocol of the IAS therapy, and the mutation rate
from androgen-dependent cells to androgen-independent ones. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1007/s00332-008-9031-0 | J. Nonlinear Science |
Keywords | DocType | Volume |
Prostate cancer,Intermittent androgen suppression,Mathematical modeling,Hybrid systems,Hysteresis,Bifurcations,34C55,37G15,65L07,92C50,93A30 | Journal | 18 |
Issue | ISSN | Citations |
6 | 0938-8974 | 6 |
PageRank | References | Authors |
0.95 | 1 | 4 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Aiko Miyamura Ideta | 1 | 9 | 1.36 |
| Gouhei Tanaka | 2 | 51 | 11.80 |
| Takumi Takeuchi | 3 | 6 | 0.95 |
| Kazuyuki Aihara | 4 | 1909 | 333.03 |