Title
A Bayes Random Fields Approach For Integrative Large-Scale Regulatory Network Analysis
Abstract
We present a Bayes-Random Fields framework which is capable of integrating unlimited data sources for discovering relevant network architecture of large-scale networks. The random field potential function is designed to impose a cluster constraint, teamed with a full Bayesian approach for incorporating heterogenous data sets. The probabilistic nature of our framework facilitates robust analysis in order to minimize the influence of noise inherent in the data on the inferred structure in a seamless and coherent manner. This is later proved in its applications to both large-scale synthetic data sets and Saccharomyces Cerevisiae data sets. The analytical and experimental results reveal the varied characteristic of different types of data and refelct their discriminative ability in terms of identifying direct gene interactions.
Year
DOI
Venue
2008
10.2390/biecoll-jib-2008-99
JOURNAL OF INTEGRATIVE BIOINFORMATICS
Keywords
Field
DocType
bayesian approach,random field,network architecture,synthetic data
Data mining,Data set,Computer science,Network architecture,Data type,Artificial intelligence,Network analysis,Probabilistic logic,Discriminative model,Bayes' theorem,Random field,Bioinformatics,Machine learning
Journal
Volume
Issue
ISSN
5
2
1613-4516
Citations 
PageRank 
References 
0
0.34
10
Authors
2
Name
Order
Citations
PageRank
Yinyin Yuan1625.38
Chang-Tsun Li293772.14