Name
Title | ||
|---|---|---|
Dysfunctional gene/protein networks in hepatitis C virus-induced hepatocellular cirrhosis and carcinoma |
Abstract | ||
|---|---|---|
Background: Although hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC), the molecular mechanisms of HCV-induced transformation remain largely unknown. Cirrhosis is a transition state from normal liver to tumorigenesis in HCV-induced HCC; thus, studying the carcinogenic effects of cirrhosis could improve understanding of hepatocellular tumorigenesis. Results: In this study, the gene expression profiles of 19 normal, 58 cirrhotic, and 47 HCC liver tissues were used to identify dysfunctional gene/protein networks in cirrhosis and HCC. Dysfunctional interaction score was calculated by integrating the statistical p values of differential expression and correlated expression. The distribution of dysfunctional scores was used to identify dysfunctional elements of each network. More cancer genes were found to be enriched in the dysfunctional interactions of cirrhotic livers than in those of HCC livers. This may suggest that many cancer genes begin to change in the cirrhosis stage. The relationship between dysfunctional networks and HCV infection also was analyzed. Based on our results and earlier research, we hypothesize that the HCV protein CORE regulates human nuclear factor Yin Yang 1 (YY1) and that YY1 subsequently amplifies and transmits the CORE signal to the insulin, Jak/STAT, and TGFß pathways. Conclusions: Our results may help understanding of the mechanism of HCV-induced malignant transformation and providing clues to cirrhosis and HCC therapy or prevention. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1145/1854776.1854873 | BCB |
Keywords | Field | DocType |
hcv-induced hcc,dysfunctional interaction score,dysfunctional element,hcc therapy,hepatocellular cirrhosis,dysfunctional gene,hcc liver,cancer gene,dysfunctional interaction,protein network,hcc liver tissue,dysfunctional network,hepatitis c,mirna,microrna,transition state,rna seq,molecular mechanics,risk factors,mcf 7 | Carcinogenesis,Cirrhosis,YY1,Hepatocellular carcinoma,Biology,Dysfunctional family,microRNA,Malignant transformation,Hepatitis C virus,Bioinformatics | Conference |
Citations | PageRank | References |
1 | 0.50 | 3 |
Authors | ||
9 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Tao Huang | 1 | 41 | 10.56 |
| Guohui Ding | 2 | 129 | 17.14 |
| Yixue Li | 3 | 789 | 60.24 |
| Lei Liu | 4 | 27 | 24.35 |
| Eugene Tan | 5 | 6 | 1.59 |
| Hongyue Dai | 6 | 95 | 9.00 |
| Qi Liu | 7 | 568 | 49.57 |
| Zhidong Tu | 8 | 124 | 10.53 |
| Lu Xie | 9 | 149 | 10.84 |