Title
Diagnosis of hypoglycemic episodes using a neural network based rule discovery system
Abstract
Hypoglycemia or low blood glucose is dangerous and can result in unconsciousness, seizures and even death for Type 1 diabetes mellitus (T1DM) patients. Based on the T1DM patients' physiological parameters, corrected QT interval of the electrocardiogram (ECG) signal, change of heart rate, and the change of corrected QT interval, we have developed a neural network based rule discovery system with hybridizing the approaches of neural networks and genetic algorithm to identify the presences of hypoglycemic episodes for TIDM patients. The proposed neural network based rule discovery system is built and is validated by using the real T1DM patients' data sets collected from Department of Health, Government of Western Australia. Experimental results show that the proposed neural network based rule discovery system can achieve more accurate results on both trained and unseen T1DM patients' data sets compared with those developed based on the commonly used classification methods for medical diagnosis, statistical regression, fuzzy regression and genetic programming. Apart from the achievement of these better results, the proposed neural network based rule discovery system can provide explicit information in the form of production rules which compensate for the deficiency of traditional neural network method which do not provide a clear understanding of how they work in prediction as they are in an implicit black-box structure. This explicit information provided by the product rules can convince medical doctors to use the neural networks to perform diagnosis of hypoglycemia on T1DM patients.
Year
DOI
Venue
2011
10.1016/j.eswa.2011.02.020
Expert Syst. Appl.
Keywords
Field
DocType
explicit information,t1dm patient,neural network,neural networks,rule discovery system,production rule,hypoglycemic episode,hypoglycemic episodes,traditional neural network method,corrected qt interval,medical diagnosis,genetic algorithm,qt interval,product rule,proposed neural network,type 1 diabetes mellitus
Data mining,Data set,QT interval,Product rule,Computer science,Regression analysis,Genetic programming,Artificial intelligence,Artificial neural network,Genetic algorithm,Medical diagnosis,Machine learning
Journal
Volume
Issue
ISSN
38
8
Expert Systems With Applications
Citations 
PageRank 
References 
18
0.81
20
Authors
4
Name
Order
Citations
PageRank
K. Y. Chan1784.77
S. H. Ling260940.29
Tharam S. Dillon32573340.98
H. T. Nguyen4180.81