Paper Info
Title
3D Computational Mechanical Analysis for Human Atherosclerotic Plaques Using MRI-Based Models with Fluid-Structure Interactions
Abstract
Atherosclerotic plaques may rupture without warning and cause acute cardiovascular syndromes such as heart attack and stroke. It is believed that mechanical forces play an important role in plaque progression and rupture. A three-dimensional (3D) MRI-based finite-element model with multicomponent plaque structure and fluid-structure interactions (FSI) is introduced to perform mechanical analysis for human atherosclerotic plaques and identify critical flow and stress/strain conditions which may be related to plaque rupture. The coupled fluid and structure models are solved by ADINA, a well-tested finite-element package. Our results indicate that pressure conditions, plaque structure, component size and location, material properties, and model assumptions all have considerable effects on flow and plaque stress/strain behaviors. Large-scale patient studies are needed to validate the computational findings. This FSI model provides more complete stress/strain analysis and better interpretation of information from MR images and may lead to more accurate plaque vulnerability assessment and rupture predictions.
Year
DOI
Venue
2004
10.1007/978-3-540-30136-3_41
Lecture Notes in Computer Science
Keywords
Field
DocType
vulnerability assessment,three dimensional,finite element,finite element model,computational mechanics,material properties
Biomedical engineering,Adina,Pattern recognition,Computer science,Artificial intelligence
Conference
Volume
ISSN
Citations 
3217
0302-9743
1
PageRank 
References 
Authors
0.63
0
9
Name
Order
Citations
PageRank
Dalin Tang1104.95
Chun Yang242.81
Jie Zheng382.91
Pamela K. Woodard431.51
Gregorio A. Sicard510.63
Jeffrey E. Saffitz610.63
Shunichi Kobayashi742.37
Thomas K. Pilgram8238.73
Chun Yuan9249.06