Name
Abstract | ||
|---|---|---|
The creation of models for heterogeneous and complex cellular networks is a central goal of Systems Biology. When modeling a biological network, one may wish to account for certain aspects in detail, while a bird's eye perspective would seem more appropriate for other parts. Multi-level models combine such overview and detail representations. We illustrate multi-level modeling with gene regulation of the Tryptophan operon in E. coli. We review three discrete event modeling formalisms and discuss model design therein: DEVS, STATECHARTS, and stochastic pi-CALCULUS. This introductory presentation already reveals some of their respective virtues and shortcomings. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1524/itit.2006.48.3.148 | IT-INFORMATION TECHNOLOGY |
Keywords | Field | DocType |
J.3 [Life and Medical Sciences], I.6 [Simulation and Modeling], Modeling, Simulation, Simulation Languages, Multi-Level Modeling, Discrete-event Modeling, Systems Biology | Computer science,Multilevel model,Systems biology,Theoretical computer science,Discrete event modeling | Journal |
Volume | Issue | ISSN |
48 | 3 | 1611-2776 |
Citations | PageRank | References |
2 | 0.40 | 3 |
Authors | ||
2 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Adelinde Uhrmacher | 1 | 168 | 14.98 |
| Céline Kuttler | 2 | 56 | 5.61 |