Abstract | ||
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By developing and analyzing a conductance-based network model for interactions of the external segment of the globus pallidus and the subthalamic nucleus in the basal ganglia, we test hypotheses on the origin of tremor-related synchronous activity in parkinsonian states. We find that the network robustly generates two types of synchronous rhythms. In one rhythm, isolated episodes of full-population synchronized bursting arise and repeat at 1-2 Hz. In the other rhythm, the cells split into synchronized clusters that alternate firing. We explore the mechanisms behind these rhythms as well as modulations that eliminate synchronous oscillations in the network. (C) 2001 Elsevier Science B.V. All rights reserved. |
Year | DOI | Venue |
---|---|---|
2001 | 10.1016/S0925-2312(01)00430-1 | NEUROCOMPUTING |
Keywords | Field | DocType |
basal ganglia,subthalamic nucleus,globus pallidus,synchronous oscillations | Bursting,Globus pallidus,Neuroscience,Pattern recognition,Indirect pathway of movement,Artificial intelligence,Rhythm,Subthalamic nucleus,Basal ganglia,Mathematics | Journal |
Volume | ISSN | Citations |
38 | 0925-2312 | 0 |
PageRank | References | Authors |
0.34 | 0 | 4 |
Name | Order | Citations | PageRank |
---|---|---|---|
david terman | 1 | 132 | 19.20 |
Jonathan E. Rubin | 2 | 235 | 31.34 |
a c yew | 3 | 0 | 0.34 |
charles j wilson | 4 | 8 | 2.72 |