Name
Title | ||
|---|---|---|
A Model of Ocular Dominance Column Development by Competition for Trophic Factor: Effects of Excess Trophic Factor with Monocular Deprivation and Effects of Antagonist of Trophic Factor |
Abstract | ||
|---|---|---|
Recent experimental evidence has implicated neurotrophic factors (NTs) in the competitive process believed to drive the development of ocular dominance (OD) columns. Application of excess amounts of particular NTs can prevent the segregation process, suggesting that they could be the substance for which geniculocortical afferents compete during development. We have previously presented a model that accounts for normal OD development as well as the prevention of that development with excess NT. The model uses a Hebbian learning rule in combination with competition for a limiting supply of cortical trophic factor to drive OD segregation, without any weight normalization procedures. |
Year | DOI | Venue |
|---|---|---|
2000 | 10.1023/A:1008997926773 | Journal of Computational Neuroscience |
Keywords | Field | DocType |
ocular dominance,critical period,mathematical model,neurotrophin | Neurotrophin,Trophic level,Neuroscience,Ocular dominance,Neurotrophic factors,Antagonist,Ocular dominance column,Limiting,Mathematics,Monocular deprivation | Journal |
Volume | Issue | ISSN |
8 | 3 | 1573-6873 |
Citations | PageRank | References |
2 | 0.66 | 4 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Anthony E. Harris | 1 | 2 | 0.66 |
| Bard Ermentrout | 2 | 1098 | 161.49 |
| Steven L. Small | 3 | 158 | 22.15 |