Title
A spatio-temporal deconvolution method to improve perfusion CT quantification.
Abstract
Perfusion imaging is a useful adjunct to anatomic imaging in numerous diagnostic and therapy-monitoring settings. One approach to perfusion imaging is to assume a convolution relationship between a local arterial input function and the tissue enhancement profile of the region of interest via a "residue function" and subsequently solve for this residue function. This ill-posed problem is generally solved using singular-value decomposition based approaches, and the hemodynamic parameters are solved for each voxel independently. In this paper, we present a formulation which incorporates both spatial and temporal correlations, and show through simulations that this new formulation yields higher accuracy and greater robustness with respect to image noise. We also show using rectal cancer tumor images that this new formulation results in better segregation of normal and cancerous voxels.
Year
DOI
Venue
2010
10.1109/TMI.2010.2043536
IEEE Trans. Med. Imaging
Keywords
Field
DocType
anatomic imaging,diagnostic monitoring,local arterial input function,computerised tomography,spatio-temporal deconvolution method,haemorheology,voxel segregation,ill-posed problem,spatial and temporal correlations,perfusion ct quantification,singular-value decomposition,tissue enhancement profile,deconvolution,image classification,perfusion computed tomography (ct),therapy monitoring,residue function,hemodynamic parameters,rectal cancer tumor images,singular value decomposition,medical image processing,perfusion imaging,haemodynamics,radiology,hemodynamics,rectal cancer,region of interest,convolution,computed tomography,helium,perfusion,computer simulation,biomedical imaging
Voxel,Nuclear medicine,Perfusion scanning,Medical imaging,Deconvolution,Artificial intelligence,Contextual image classification,Computer vision,Pattern recognition,Convolution,Image noise,Region of interest,Mathematics
Journal
Volume
Issue
ISSN
29
5
1558-254X
Citations 
PageRank 
References 
14
0.82
7
Authors
7
Name
Order
Citations
PageRank
Lili He1140.82
Burkay Orten2986.00
Synho Do39412.86
William Clement Karl47913.41
Avinish Kambadakone5140.82
Dushyant V Sahani6232.81
Homer Pien7446.48