Name
Abstract | ||
|---|---|---|
Gastrointestinal (GI) motility is coordinated by several cooperating mechanisms, including electrical slow wave activity, the enteric nervous system (ENS), and other factors. Slow waves generated in interstitial cells of Cajal (ICC) depolarize smooth muscle cells (SMC), generating basic GI contractions. This unique electrical coupling presents an added layer of complexity to GI electromechanical models, and a current barrier to further progress is the lack of a framework for ICC-SMC-contraction coupling. In this study, an initial framework for the electromechanical coupling was developed in a 2-D model. At each solution step, the slow wave propagation was solved first and [Ca(2+)](i) in the SMC model was related to a Ca(2+)-tension-extension relationship to simulate active contraction. With identification of more GI-specific constitutive laws and material parameters, the ICC-SMC-contraction approach may underpin future GI electromechanical models of health and disease states. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/TBME.2011.2166155 | IEEE Trans. Biomed. Engineering |
Keywords | Field | DocType |
bioelectric phenomena,biomechanics,cellular biophysics,electromechanical effects,muscle,neurophysiology,physiological models,2D model,Ca2+-tension-extension relationship,GI electromechanical model,Gl-specific constitutive law,ICC-SMC-contraction approach,SMC model,active contraction,current barrier,disease states,electrical coupling,electrical slow wave activity,enteric nervous system,gastrointestinal electromechanical coupling,gastrointestinal motility,interstitial cells,material parameters,slow wave propagation,smooth muscle cells,Bidomain,interstitial cells of Cajal (ICC),motility,slow waves,smooth muscle cells (SMC) | Cellular biophysics,Interstitial cell of Cajal,Enteric nervous system,Neuroscience,Coupling,Biological system,Wave propagation,Computer science,Electronic engineering,Depolarization,Coupling (electronics) | Journal |
Volume | Issue | ISSN |
58 | 12 | 1558-2531 |
Citations | PageRank | References |
0 | 0.34 | 1 |
Authors | ||
8 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Peng Du | 1 | 10 | 11.12 |
| Yong Cheng Poh | 2 | 0 | 0.68 |
| Jee Lean Lim | 3 | 0 | 0.34 |
| Viveka Gajendiran | 4 | 0 | 0.34 |
| Greg O'Grady | 5 | 20 | 5.39 |
| Martin L Buist | 6 | 4 | 1.43 |
| Andrew J Pullan | 7 | 69 | 15.32 |
| Leo K Cheng | 8 | 70 | 37.48 |