Name
Abstract | ||
|---|---|---|
The kinetics of proteins involved in ion transfer, sequestration and binding in cardiac cells can be modelled to construct a model of the electrical activity of isolated cardiac cells as a system of ordinary differential equations. These cell models may be incorporated into tissue models, which, when combined with histology and anatomy, form virtual tissues. The effects of changes in specific protein expression, or changes in protein kinetics, produced by mutations or pharmacological agents, can be simulated using these tissue models and used to account for the whole organ effects of changes in specific ion-transport protein activity. |
Year | DOI | Venue |
|---|---|---|
2001 | 10.1093/bib/2.3.233 | Briefings in Bioinformatics |
Keywords | Field | DocType |
kinetics,protein expression,action potential,ion channel,ion transport,partial differential equation,ordinary differential equation | Biology,Biochemistry,Protein activity,Cell biology,Cell,Protein expression,Bioinformatics,Kinetics,Histology | Journal |
Volume | Issue | ISSN |
2 | 3 | 1467-5463 |
Citations | PageRank | References |
1 | 0.63 | 1 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Mark R. Boyett | 1 | 12 | 4.87 |
| Arun V. Holden | 2 | 52 | 20.71 |
| Henggui Zhang | 3 | 105 | 51.88 |