Paper Info
Title
Imaging-based systems biology
Abstract
Arguably the most significant contribution of the human genome project is that we can now build a recombinant construct of every gene and every promotor in C. elegans (worm), D. melanogaster (fly), M. musculus (mouse), and H. sapiens (human). These include fluorescent proteins and other markers that can be induced at controlled time points via a change in temperature, light, or chemistry. Combined with tremendous advances in light and electron microscopy in recent years, I believe we are now poised to visualize the meso-scale of the cell, and development and small organs (e.g. a fly's brain) at the resolution of individual cells. Toward this end, my group is working on a number of preliminary imaging projects along these lines. These include (a) studies of development and gene expression in worms and flies, (b) neural patterning in flies and mice, and (c) the interpretation of signals from a new sub-wavelength resolution light microscope. We describe preliminary results on limited data sets and extrapolate on what we might be able to infer from such data. We further speculate on the potential implications of such work for the future of molecular biology.
Year
DOI
Venue
2006
10.1007/11945918_4
HiPC
Keywords
Field
DocType
imaging-based systems biology,c. elegans,preliminary result,new sub-wavelength resolution light,gene expression,limited data set,m. musculus,human genome project,electron microscopy,preliminary imaging project,controlled time point,system biology,molecular biology
Gene,Melanogaster,Computer science,Systems biology,Human genome,Computational biology,Bioinformatics,Distributed computing
Conference
ISBN
Citations 
PageRank 
3-540-68039-X
0
0.34
References 
Authors
1
1
Name
Order
Citations
PageRank
Eugene Myers13164496.92