Name
Abstract | ||
|---|---|---|
A previously described method for partitioning amino acid dihedral angle space generates a set of cluster centers which may be used to represent residue backbones in three dimensional protein structures [Id]. 99 non-homologous polypeptide chains are eztracted from Brookhaven Protein D ata B ank files and abstracted into sequences of these cluster centers, then this data set is ezamined for repeated sub-sequences. Repeated sequences of amino acid conformational clusters indicate duplicated motifs or sub-structures in folded proteins, independent of amino acid sequence identity. This representation is significantly more detailed than standard secondary structure descriptors (heliz, strand, turn, etc.) and facilitates the identification of common structural elements without regard to sequence length. The current work ezamines the degree to which three ezample proteins share sub-structures with the remainder of the data set (ribonuclease A, erythrocruorin, and actinozanthin), the specification of a-helices and \u0026strands under this system, and the sensitivity of the method to visual diflerences between structures. |
Year | DOI | Venue |
|---|---|---|
1994 | 10.1109/HICSS.1994.323573 | HICSS |
Keywords | Field | DocType |
factographic databases,macromolecules,medical administrative data processing,medical image processing,proteins,/spl alpha/-helices,/spl beta/-strands,Brookhaven Protein Data Bank files,actinozanthin,amino acid conformational clusters,amino acid dihedral angle space,amino acid sequence identity,cluster centers,common structural elements,data set,duplicated motifs,erythrocruorin,folded proteins,non-homologous polypeptide chains,repeated structural elements,repeated sub-sequences,residue backbones,ribonuclease A,three dimensional protein structures,visual differences | Computer science,Amino acid,Knowledge management,Helix,Stereochemistry,Bioinformatics,Erythrocruorin,Protein Data Bank,Protein secondary structure,Dihedral angle,Peptide sequence,Protein structure | Conference |
Volume | Citations | PageRank |
5 | 0 | 0.34 |
References | Authors | |
0 | 3 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| R. T. Miller | 1 | 0 | 0.34 |
| Richard J. Douthart | 2 | 0 | 0.68 |
| A. Keith Dunker | 3 | 466 | 77.54 |