Title
Gripper Synthesis For Indirect Manipulation Of Cells Using Holographic Optical Tweezers
Abstract
Optical Tweezers (OT) are used for highly accurate manipulations of biological cells. However, the direct exposure of cells to focused laser beam may negatively influence their biological functions. In order to overcome this problem, we generate multiple optical traps to grab and move a 3D ensemble of inert particles such as silica microspheres to act as a reconfigurable gripper for a manipulated cell. The relative positions of the microspheres are important in order for the gripper to be robust against external environmental forces and the exposure of high intensity laser on the cell to be minimized. In this paper, we present results of different gripper configurations, experimentally tested using our OT setup, that provide robust gripping as well as minimize laser intensity experienced by the cell. We developed a computational approach that allowed us to perform preliminary modeling and synthesis of the gripper configurations. The gripper synthesis is cast as a multi-objective optimization problem.
Year
DOI
Venue
2012
10.1109/ICRA.2012.6225153
2012 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)
Keywords
Field
DocType
optical trapping,holography,microspheres,force,optical tweezer,robustness
Holography,Robustness (computer science),Laser,Control engineering,Optical tweezers,Engineering,Grippers,Microsphere,Optimization problem,Laser beams
Conference
Volume
Issue
ISSN
2012
1
1050-4729
Citations 
PageRank 
References 
0
0.34
4
Authors
5
Name
Order
Citations
PageRank
Sagar Chowdhury1686.48
Petr Svec2626.68
Chenlu Wang3262.89
Wolfgang Losert4898.53
Satyandra K Gupta568777.11