Paper Info
Title
The Impact Of High Density Receptor Clusters On Vegf Signaling
Abstract
Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization. Herein, we discuss experimental evidence that VEGF receptors localize in caveloae and other regions of the plasma membrane, and for other receptors, it has been shown that receptor clustering has an impact on dimerization and thus also on signaling. Overall, receptor clustering is part of a complex ecosystem of interactions and how receptor clustering impacts dimerization is not well understood. To address these questions, we have formulated the simplest possible model. We have postulated the existence of a single high affinity region in the cell membrane, which acts as a transient trap for receptors. We have defined an ODE model by introducing high-and low-density receptor variables and introduce the corresponding reactions from a realistic model of VEGF signal initiation. Finally, we use the model to investigate the relation between the degree of VEGFR concentration, ligand availability, and signaling. In conclusion, our simulation results provide a deeper understanding of the role of receptor clustering in cell signaling.
Year
DOI
Venue
2013
10.4204/EPTCS.125.3
ELECTRONIC PROCEEDINGS IN THEORETICAL COMPUTER SCIENCE
Keywords
Field
DocType
biomedical research,bioinformatics
VEGF signaling,Ligand,Control theory,Cell biology,High density,Receptor,Cell membrane,Vascular endothelial growth factor,Cell signaling,Bioinformatics,Receptor clustering,Mathematics
Journal
Volume
Issue
ISSN
2013
125
2075-2180
Citations 
PageRank 
References 
0
0.34
1
Authors
4
Name
Order
Citations
PageRank
Ye Chen1667.20
Christopher Short201.01
Ádám Halász320313.41
Jeremy S Edwards48412.49