Title
PyNAST: a flexible tool for aligning sequences to a template alignment
Abstract
Motivation: The Nearest Alignment Space Termination (NAST) tool is commonly used in sequence-based microbial ecology community analysis, but due to the limited portability of the original implementation, it has not been as widely adopted as possible. Python Nearest Alignment Space Termination (PyNAST) is a complete reimplementation of NAST, which includes three convenient interfaces: a Mac OS X GUI, a command-line interface and a simple application programming interface (API). Results: The availability of PyNAST will make the popular NAST algorithm more portable and thereby applicable to datasets orders of magnitude larger by allowing users to install PyNAST on their own hardware. Additionally because users can align to arbitrary template alignments, a feature not available via the original NAST web interface, the NAST algorithm will be readily applicable to novel tasks outside of microbial community analysis.
Year
DOI
Venue
2010
10.1093/bioinformatics/btp636
BIOINFORMATICS
Field
DocType
Volume
Computer science,Community analysis,Software,Application programming interface,Software portability,OS X,Bioinformatics,User interface,Python (programming language)
Journal
26
Issue
ISSN
Citations 
2
1367-4803
6
PageRank 
References 
Authors
0.70
2
6
Name
Order
Citations
PageRank
J. Gregory Caporaso1344.56
Kyle Bittinger2131.68
Frederic D Bushman3194.05
Todd Z. DeSantis481.50
Gary L. Andersen5293.87
Rob Knight636626.19