Name
Title | ||
|---|---|---|
Towards argument-driven validation of an in silico model of immune tissue organogenesis |
Abstract | ||
|---|---|---|
Specialised tissues of the immune system including lymph nodes, tonsils, spleen and Peyer’s Patches have key roles in the
initiation of adaptive immune responses to infection. To understand the molecular mechanisms involved in the development of
this tissue, mice deficient for key genes in this process have been developed and analysed, leading to a basic model describing
tissue formation. Although this approach has provided some key insights into the molecular mechanisms involved, due to the
complexity of gene expression patterns it has not been possible to fully understand the process of lymphoid tissue organogenesis.
|
Year | DOI | Venue |
|---|---|---|
2011 | 10.1007/978-3-642-22371-6_7 | ICARIS |
Keywords | Field | DocType |
immune tissue organogenesis,silico model,towards argument-driven validation | Gene,Biology,Cell biology,Organogenesis,Immune system,Artificial intelligence,Experimental autoimmune encephalomyelitis,In silico,Spleen,Immunology,Gene expression,Machine learning,Lymphatic system | Conference |
Citations | PageRank | References |
1 | 0.35 | 2 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Kieran Alden | 1 | 12 | 3.37 |
| Paul S. Andrews | 2 | 285 | 23.82 |
| Jon Timmis | 3 | 1237 | 120.32 |
| Henrique Veiga-Fernandes | 4 | 8 | 1.36 |
| Mark Coles | 5 | 9 | 2.72 |