Name
Title | ||
|---|---|---|
Ontological modeling at a domain interface: Bridging clinical and biomolecular knowledge |
Abstract | ||
|---|---|---|
In this paper, we discuss the challenges posed by the NEUROWEB project, as a case study of ontological modeling at a knowledge interface between neurovascular medicine and genomics. The aim of the project is the development of a support system for association studies. We identify the notion of clinical phenotypes, that is, the pathological condition of a patient, as the central construct of the knowledge model. Clinical phenotypes are assessed through the diagnostic activity, performed by clinical experts operating within communities of practice; the different communities operate according to specific procedures, but they also conform to the minimal requirements of international guidelines, displayed by the adoption of a common standard for the patient classification. We develop a central model for the clinical phenotypes, able to reconcile the different methodologies into a common classificatory system. To bridge neurovascular medicine and genomics, we identify the general theory of biological function as the common ground between the two disciplines; therefore, we decompose the clinical phenotypes into elementary phenotypes with a homogeneous physiological background, and we connect them to the biological processes, acting as the elementary units of the genomic world. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1017/S0269888909990026 | Knowledge Eng. Review |
Keywords | Field | DocType |
domain interface,biological process,biological function,elementary phenotypes,common standard,clinical expert,ontological modeling,clinical phenotypes,biomolecular knowledge,neurovascular medicine,common classificatory system,common ground,neuroweb project | Ontology,Homogeneous,Computer science,Support system,Bridging (networking),Knowledge management,Systems biology,Genomics,Common ground,Health informatics | Journal |
Volume | Issue | ISSN |
24 | 3 | 0269-8889 |
Citations | PageRank | References |
0 | 0.34 | 23 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Gianluca Colombo | 1 | 45 | 4.09 |
| Daniele Merico | 2 | 13 | 3.19 |
| Zoltá/n Nagy | 3 | 0 | 0.34 |
| flavio de paoli | 4 | 426 | 48.24 |
| Marco Antoniotti | 5 | 102 | 18.50 |
| Giancarlo Mauri | 6 | 2106 | 297.38 |