Paper Info
Title
A feedback quenched oscillator produces turing patterning with one diffuser.
Abstract
Efforts to engineer synthetic gene networks that spontaneously produce patterning in multicellular ensembles have focused on Turing's original model and the "activator-inhibitor" models of Meinhardt and Gierer. Systems based on this model are notoriously difficult to engineer. We present the first demonstration that Turing pattern formation can arise in a new family of oscillator-driven gene network topologies, specifically when a second feedback loop is introduced which quenches oscillations and incorporates a diffusible molecule. We provide an analysis of the system that predicts the range of kinetic parameters over which patterning should emerge and demonstrate the system's viability using stochastic simulations of a field of cells using realistic parameters. The primary goal of this paper is to provide a circuit architecture which can be implemented with relative ease by practitioners and which could serve as a model system for pattern generation in synthetic multicellular systems. Given the wide range of oscillatory circuits in natural systems, our system supports the tantalizing possibility that Turing pattern formation in natural multicellular systems can arise from oscillator-driven mechanisms.
Year
DOI
Venue
2012
10.1371/journal.pcbi.1002331
PLOS COMPUTATIONAL BIOLOGY
Keywords
Field
DocType
oscillations,pattern formation,gene regulatory networks,computer simulation,stochastic simulation,feedback loop,feedback,gene network
Multicellular organism,Computer science,Feedback loop,Network topology,Pattern formation,Turing,Bioinformatics,Electronic circuit,Gene regulatory network,Partial differential equation
Journal
Volume
Issue
ISSN
8
1
1553-7358
Citations 
PageRank 
References 
6
0.64
1
Authors
5
Name
Order
Citations
PageRank
Justin Hsia1112.96
William J Holtz271.03
Daniel C Huang3432.97
murat arcak41855195.31
Michel M Maharbiz58820.12