Paper Info
Title
G2cdb: The Genes To Cognition Database
Abstract
Neuroscience databases linking genes, proteins, (patho)physiology, anatomy and behaviour across species will be valuable in a broad range of studies of the nervous system. G2Cdb is such a neuroscience database aiming to present a global view of the role of synapse proteins in physiology and disease. G2Cdb warehouses sets of genes and proteins experimentally elucidated by proteomic mass spectroscopy of signalling complexes and proteins biochemically isolated from mammalian synapse preparations, giving an experimentally validated definition of the constituents of the mammalian synapse. Using automated text-mining and expert (human) curation we have systematically extracted information from published neurobiological studies in the fields of synaptic signalling electrophysiology and behaviour in knockout and other transgenic mice. We have also surveyed the human genetics literature for associations to disease caused by mutations in synaptic genes. The synapse proteome datasets that G2Cdb provides offer a basis for future work in synapse biology and provide useful information on brain diseases. They have been integrated in a such way that investigators can rapidly query whether a gene or protein is found in brain-signalling complex(es), has a phenotype in rodent models or whether mutations are associated with a human disease. G2Cdb can be freely accessed at http://www.genes2cognition.org.
Year
DOI
Venue
2009
10.1093/nar/gkn700
NUCLEIC ACIDS RESEARCH
Field
DocType
Volume
Human genetics,Synapse,Disease,Gene,Phenotype,Proteomics,Biology,Proteome,Genetics,Database,Mutation
Journal
37
Issue
ISSN
Citations 
Database-I
0305-1048
2
PageRank 
References 
Authors
0.52
11
5
Name
Order
Citations
PageRank
Michael D. R. Croning1291105.40
Michael C. Marshall220.52
Peter Mclaren320.52
Douglas Armstrong41339.33
Seth G. N. Grant551.02