Name
Title | ||
|---|---|---|
Complexities and Algorithms for Glycan Structure Sequencing using Tandem Mass Spectrometry |
Abstract | ||
|---|---|---|
Determining glycan structures is vital to comprehend cell-matrix, cell-cell, and even intracellular biological events. Glycan structure sequencing, which is to determine the primary structure of a glycan using MS/MS spectrometry, remains one of the most important tasks in proteomics. Analogous to the peptide de novo sequencing, the glycan de novo sequencing is to determine the structure without the aid of a known glycan database. We show in this paper that glycan de novo sequencing is NP-hard. We then provide a heuristic algorithm and develop a software program to solve the problem in practical cases. Experiments on real MS/MS data of glycopeptides demonstrate that our heuristic algorithm gives satisfactory results on practical data. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1142/9781860947995_0032 | Series on Advances in Bioinformatics and Computational Biology |
Keywords | Field | DocType |
tandem mass spectrometry,heuristic algorithm | Biology,Proteomics,Tandem mass spectrometry,Mass spectrometry,Bioinformatics,Glycan | Conference |
Volume | ISSN | Citations |
5 | 1751-6404 | 1 |
PageRank | References | Authors |
0.37 | 5 | 4 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Baozhen Shan | 1 | 24 | 4.59 |
| Bin Ma | 2 | 1758 | 155.63 |
| Kaizhong Zhang | 3 | 2303 | 514.76 |
| Gilles Lajoie | 4 | 13 | 3.60 |