Name
Abstract | ||
|---|---|---|
Tandem mass spectrometry is a popular tool for the identification of peptide sequences. In this paper, we present a method for rapid generation of short peptide sequences via tandem mass spectrometry based on a graph search. The approach takes advantage of several pairs of peaks that have high intensities. We proposed a pair peak value set (PPS) and used the pair peak values of highest intensities as the root of a tree. The other nodes are viewed as the reference nodes to find the most promising path. We aimed to determine the peptide sequences for MS/MS spectra that have low signal-to-noise ratios. Our experiment on 2420 experimental MS/MS spectra with two PTMs shows that our algorithm achieves better accuracy than PepNovo approaches with higher efficiency. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/BIBMW.2011.6112383 | BIBM Workshops |
Keywords | Field | DocType |
graph search,rapid generation,better accuracy,short peptide sequence,pair peak value set,ms spectrum,tandem mass spectrometry,graph search algorithm,pepnovo approach,pair peak value,experimental ms,peptide sequence,peptide sequence tag,signal to noise ratio,spectrum,mass spectroscopy,polymers,post translational modification | Peak value,Graph,Graph traversal,Computer science,Peptide,Tandem mass spectrometry,Mass spectrometry,Bioinformatics,Peptide sequence | Conference |
ISSN | Citations | PageRank |
2163-6966 | 0 | 0.34 |
References | Authors | |
0 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Hui Li | 1 | 3 | 5.46 |
| Chun-Mei Liu | 2 | 245 | 41.30 |
| Mugizi Rwebangira | 3 | 5 | 1.51 |
| Legand Burge | 4 | 29 | 9.60 |
| William Southerland | 5 | 15 | 6.23 |