Title
Structure-Function Relationships Of The Sinoatrial Node
Abstract
The sinoatrial node, the pacemaker of the heart, is a structurally and functionally complex and heterogeneous structure. Histology, immunohistochemistry, electrophysiology and mathematical modeling of the sinoatrial node are reviewed to reveal the structure-function relationships of the sinoatrial node. It is argued that contact between the sinoatrial node and surrounding atrial muscle is limited to permit driving of the atrial muscle by the sinoatrial node but not suppression of the sinoatrial node by the atrial muscle (which is more hyperpolarized). It is argued that a protective conduction block zone on one side of the sinoatrial node is the result of a lack of myocytes. Finally, it is argued that the cellular organization of the sinoatrial node is best described by the gradient model.
Year
DOI
Venue
2003
10.1142/S0218127403008831
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
Keywords
DocType
Volume
sinoatrial node, sinus node, pacemaker
Journal
13
Issue
ISSN
Citations 
12
0218-1274
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
Halina Dobrzynski111.64
Henggui Zhang210551.88
Sally E. Wright300.34
Arun V. Holden45220.71
Mark R. Boyett5124.87