Name
Title | ||
|---|---|---|
Stochastic Modelling and Simulation of Coupled Autoregulated Oscillators in a Multicellular Environment: The her1/her7 Genes |
Abstract | ||
|---|---|---|
Delays are an important feature in temporal models of genetic regulation due to slow biochemical processes such as transcription and translation. In this paper we show how to model intrinsic noise effects in a delayed setting. As a particular application we apply these ideas to modelling somite segmentation in zebrafish across a number of cells in which two linked oscillatory genes her1 and her7 are synchronized via Notch signalling between the cells. |
Year | DOI | Venue |
|---|---|---|
2007 | 10.1007/978-3-540-72584-8_103 | International Conference on Computational Science |
Keywords | Field | DocType |
delay stochastic simulation algorithm, coupled regulatory systems, multicellular environment, multiscale modelling | Mathematical optimization,Oscillation,Gene,Multicellular organism,Biological system,Simulation,Segmentation,Computer science,Zebrafish,Somite,Stochastic modelling,Notch signaling pathway | Conference |
Volume | ISSN | Citations |
4487 | 0302-9743 | 1 |
PageRank | References | Authors |
0.35 | 2 | 3 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| André Leier | 1 | 197 | 19.87 |
| Kevin Burrage | 2 | 315 | 37.67 |
| Pamela Burrage | 3 | 19 | 7.59 |