Title
Contrast Limited Adaptive Histogram Equalization image processing to improve the detection of simulated spiculations in dense mammograms
Abstract
The purpose of this project was to determine whether Contrast Limited Adaptive Histogram Equalization (CLAHE) improves detection of simulated spiculations in dense mammograms. Lines simulating the appearance of spiculations, a common marker of malignancy when visualized with masses, were embedded in dense mammograms digitized at 50 micron pixels, 12 bits deep. Film images with no CLAHE applied were compared to film images with nine different combinations of clip levels and region sizes applied. A simulated spiculation was embedded in a background of dense breast tissue, with the orientation of the spiculation varied. The key variables involved in each trial included the orientation of the spiculation, contrast level of the spiculation and the CLAHE settings applied to the image. Combining the 10 CLAHE conditions, 4 contrast levels and 4 orientations gave 160 combinations. The trials were constructed by pairing 160 combinations of key variables with 40 backgrounds. Twenty student observers were asked to detect the orientation of the spiculation in the image. There was a statistically significant improvement in detection performance for spiculations with CLAHE over unenhanced images when the region size was set at 32 with a clip level of 2, and when the region size was set at 32 with a clip level of 4. The selected CLAHE settings should be tested in the clinic with digital mammograms to determine whether detection of spiculations associated with masses detected at mammography can be improved.
Year
DOI
Venue
1998
10.1007/BF03178082
J. Digital Imaging
Keywords
Field
DocType
mammography,image processing,contrast limited adaptive histogram equalization,observer studies,breast cancer,spiculations
Computer vision,Mammography,Computer science,Image processing,Adaptive histogram equalization,Pixel,Artificial intelligence,Radiographic Image Enhancement
Journal
Volume
Issue
ISSN
11
4
0897-1889
Citations 
PageRank 
References 
88
3.77
3
Authors
8
Name
Order
Citations
PageRank
Etta D. Pisano134449.06
Shuquan Zong2883.77
Bradley M. Hemminger345638.24
Marla DeLuca4915.55
R. Eugene Johnston511815.87
Keith Muller615813.40
M. Patricia Braeuning7937.04
Stephen M. Pizer82000262.21