Name
Abstract | ||
|---|---|---|
Our goal is to decompose whole slide images (WSI) of histology sections into distinct patches (e.g., viable tumor, necrosis) so that statistics of distinct histopathology can be linked with the outcome. Such an analysis requires a large cohort of histology sections that may originate from different laboratories, which may not use the same protocol in sample preparation. We have evaluated a method based on a variation of the restricted Boltzmann machine (RBM) that learns intrinsic features of the image signature in an unsupervised fashion. Computed code, from the learned representation, is then utilized to classify patches from a curated library of images. The system has been evaluated against a dataset of small image blocks of 1k-by-1k that have been extracted from glioblastoma multiforme (GBM) and clear cell kidney carcinoma (KIRC) from the cancer genome atlas (TCGA) archive. The learned model is then projected on each whole slide image (e.g., of size 20k-by-20k pixels or larger) for characterizing and visualizing tumor architecture. In the case of GBM, each WSI is decomposed into necrotic, transition into necrosis, and viable. In the case of the KIRC, each WSI is decomposed into tumor types, stroma, normal, and others. Evaluation of 1400 and 2500 samples of GBM and KIRC indicates a performance of 84% and 81%, respectively. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1109/ISBI.2013.6556499 | ISBI |
Keywords | DocType | Volume |
restricted boltzmann machine,cancer genome atlas,viable tumor,image representation,cellular biophysics,tcga,whole slide imaging,statistical analysis,whole slide images,learning (artificial intelligence),tumor architecture,sparse feature learning,feature learning,sparse coding,tumor characterization,boltzmann machines,cancer,gbm,image classification,tumor histopathology,stroma tumor,kidney,tumours,kirc,wsi decomposition,cell kidney carcinoma,necrosis,medical image processing,glioblastoma multiforme,image signature,encoding,biomedical research,image reconstruction,bioinformatics,learning artificial intelligence,computer architecture,dictionaries | Conference | 2013 |
ISSN | ISBN | Citations |
1945-7928 | 978-1-4673-6456-0 | 18 |
PageRank | References | Authors |
0.84 | 10 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nandita Nayak | 1 | 34 | 1.52 |
| Hang Chang | 2 | 374 | 29.11 |
| Alexander Borowsky | 3 | 80 | 5.39 |
| Paul Spellman | 4 | 453 | 43.25 |
| Bahram Parvin | 5 | 995 | 65.01 |