Name
Title | ||
|---|---|---|
A Three Dimensional Ventricular E-Cell (3Dv E-Cell) with Stochastic Intracellular Ca 2 + Handling |
Abstract | ||
|---|---|---|
To investigate the mechanisms underlying the initiation and propagation of intracellular Ca
2 + waves, we developed a three-dimensional ventricular E-Cell (3Dv E-Cell), where cell membrane, nucleus, ryanodine receptor
clusters, Z-disk, cytoplasm are modeled as spatially distributed structures. For the simulation of Ca
2 + sparks and Ca
2 + diffusion, a modified Fire-Diffuse-Fire model is used with stochastic rules for triggering Ca
2 + release. The 3Dv E-Cell is used to illustrate how stochastic properties of Ca
2 + sparks can lead to complex spatio-temporal intracellular wave processes and allows the incorporation of spatial data sets
(protein distribution) into the geometry.
|
Year | DOI | Venue |
|---|---|---|
2007 | 10.1007/978-3-540-72907-5_19 | FIMH |
Keywords | Field | DocType |
ryanodine receptor,three dimensional,spatial data | Nanotechnology,Nucleus,Biophysics,Cytoplasm,Intracellular,Chemistry,Endoplasmic reticulum,Protein distribution,Cell membrane,Cell,Ryanodine receptor | Conference |
Citations | PageRank | References |
1 | 0.48 | 2 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Pan Li | 1 | 1 | 0.48 |
| Matthew Lancaster | 2 | 1 | 0.48 |
| Arun V. Holden | 3 | 52 | 20.71 |