Name
Title | ||
|---|---|---|
Topological basis of signal integration in the transcriptional-regulatory network of the yeast, Saccharomyces cerevisiae |
Abstract | ||
|---|---|---|
BACKGROUND. Signal recognition and information processing is a fundamental
cellular function, which in part involves comprehensive transcriptional
regulatory (TR) mechanisms carried out in response to complex environmental
signals in the context of the cell's own internal state. However, the network
topological basis of developing such integrated responses remains poorly
understood.
RESULTS. By studying the TR network of the yeast Saccharomyces cerevisiae we
show that an intermediate layer of transcription factors naturally segregates
into distinct subnetworks. In these topological units transcription factors are
densely interlinked in a largely hierarchical manner and respond to external
signals by utilizing a fraction of these subnets.
CONCLUSIONS. As transcriptional regulation represents the "slow" component of
overall information processing, the identified topology suggests a model in
which successive waves of transcriptional regulation originating from distinct
fractions of the TR network control robust integrated responses to complex
stimuli. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1186/1471-2105-7-478 | BMC Bioinformatics |
Keywords | Field | DocType |
Gene Ontology, Regulatory Interaction, Transcriptional Regulatory Network, Outgoing Link, Saccharomyces Genome Database | Topology,Biology,Gene ontology,Yeast,Saccharomyces cerevisiae Proteins,Saccharomyces cerevisiae,Bioinformatics,Genetics,Gene regulatory network,DNA microarray,Transcription factor | Journal |
Volume | Issue | ISSN |
7 | 1 | 1471-2105 |
Citations | PageRank | References |
25 | 0.69 | 3 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Illés J. Farkas | 1 | 355 | 18.46 |
| Chuang Wu | 2 | 25 | 0.69 |
| Chakra Chennubhotla | 3 | 89 | 12.70 |
| Ivet Bahar | 4 | 361 | 39.41 |
| Zoltán N. Oltvai | 5 | 121 | 10.87 |