Name
Abstract | ||
|---|---|---|
Previously, we proposed using an interpolated average CT (IACT) method for attenuation correction (AC) in positron emission tomography (PET), which is a good, low-dose approximation of cine average CT (CACT) to reduce misalignments and improve quantification in PET/CT. This study aims to evaluate the performance of IACT for different motion amplitudes. We used the digital four-dimensional (4-D) extended cardiac-torso phantom (XCAT) to simulate maximum of 2, 3, and 4 cm respiratory motions. The respiratory cycle was divided into 13 phases, with average activity and attenuation maps to represent F-18-fluorodeoxyglucose (F-18-FDG) distributions with average respiratory motions and CACT, respectively. The end-inspiration, end-expiration, and midrespiratory phases of the XCAT attenuation maps represented three different helical CTs (i.e., HCT-1, HCT-5, and HCT-8). The IACTs were generated using: 1) 2 extreme + 11 interpolated phases (IACT(2o)); 2) 2 phases right after the extreme phases + 11 interpolated phases (IACT(2s)); 3) 4 original + 9 interpolated phases (IACT(4o)). A spherical lesion with a target-to-background ratio (TBR) of 4:1 and a diameter of 25 mm was placed in the base of right lung. The noise-free and noisy sinograms with attenuation modeling were generated and reconstructed with different noise-free and noisy AC maps (CACT, HCTs, and IACTs) by Software for Tomographic Image Reconstruction, respectively, using ordered subset expectation maximization(OS-EM) with up to 300 updates. Normalized mean-square error, mutual information (MI), TBR, image profile, and noise-contrast tradeoff were analyzed. The PET reconstructed images with AC using CACT showed least difference as compared to the original phantom, followed by IACT(4o), IACT(2o), IACT(2s), HCT-5, HCT-8, and HCT-1. Significant artifacts were observed in the reconstructed images using HCTs for AC. The MI differences between IACT(2o) and IACT(4o)/CACT were <0.41% and <2.17%, respectively. With a slight misplacement of the two extreme phases, IACT(2s) was still comparable to IACT(2o) with MI difference of <2.23%. The IACT is a robust and accurate low-dose alternate to CACT. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1109/TBME.2013.2245132 | IEEE Trans. Biomed. Engineering |
Keywords | Field | DocType |
interpolation,out of order,noise measurement,image reconstruction,computed tomography | Iterative reconstruction,Nuclear medicine,Imaging phantom,Dosimetry,Positron emission tomography,Ordered subset expectation maximization,For Attenuation Correction,Attenuation,IACT,Physics | Journal |
Volume | Issue | ISSN |
60 | 7 | 0018-9294 |
Citations | PageRank | References |
1 | 0.37 | 2 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| greta s p mok | 1 | 1 | 0.37 |
| tao sun | 2 | 1 | 0.37 |
| tunghsin wu | 3 | 1 | 0.37 |
| mubai chang | 4 | 1 | 0.37 |
| tzungchi huang | 5 | 12 | 2.53 |