Name
Abstract | ||
|---|---|---|
In the last decades beside conventional cancer treatment methods, molecular targeted therapies show prosperous results. These therapies have limited side-effects, and in comparison to chemotherapy, tumorous cells show lower tendency of becoming resistant to the applied antiangiogenic drugs. In clinical research, antiangiogenic therapy is one of the most promising cancer treatment methods. Using a simplified model of the reference dynamical model for tumor growth under angiogenic inhibition from the literature, exact linearization is performed in the paper to handle the nonlinear behavior of the model. Two different control methods are applied on the linearized model: flat control and switching control. Simulations are performed on the nonlinear model to show the characteristics of the therapies carried out using the presented control methods. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1109/CDC.2013.6760184 | CDC |
Keywords | Field | DocType |
cancer,feedback,linearisation techniques,medical control systems,nonlinear control systems,patient treatment,time-varying systems,tumours,antiangiogenic drugs,antiangiogenic therapy,cancer treatment,chemotherapy,clinical research,feedback linearization,flat control,linearized model,model-based angiogenic inhibition,molecular targeted therapies,nonlinear behavior,nonlinear model,reference dynamical model,switching control,tumor growth,tumorous cells | Control theory,Computer science,Feedback linearization,Molecular Targeted Therapies,Angiogenic Inhibition,Nonlinear model,Cancer,Linearization,Patient treatment | Conference |
ISSN | Citations | PageRank |
0743-1546 | 2 | 0.63 |
References | Authors | |
0 | 5 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Annamária Szeles | 1 | 10 | 2.06 |
| Dániel Andras Drexler | 2 | 17 | 6.29 |
| Johanna Sápi | 3 | 16 | 4.80 |
| István Harmati | 4 | 44 | 6.49 |
| Levente Kovács | 5 | 98 | 38.25 |