Paper Info
Title
Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae.
Abstract
Besides being the favorite carbon and energy source for the budding yeast Sacchromyces cerevisiae, glucose can act as a signaling molecule to regulate multiple aspects of yeast physiology. Yeast cells have evolved several mechanisms for monitoring the level of glucose in their habitat and respond quickly to frequent changes in the sugar availability in the environment: the cAMP/PKA pathways (with its two branches comprising Ras and the Gpr1/Gpa2 module), the Rgt2/Snf3-Rgt1 pathway and the main repression pathway involving the kinase Snf1. The cAMP/PKA pathway plays the prominent role in responding to changes in glucose availability and initiating the signaling processes that promote cell growth and division. Snf1 the yeast homologous to mammalian AMP-activated protein kinase) is primarily required for the adaptation of yeast cell to glucose limitation and for growth on alternative carbon source, but it is also involved in the cellular response to various environmental stresses. The Rgt2/Snf3-Rgt1 pathway regulates the expression of genes required for glucose uptake. Many interconnections exist between the diverse glucose sensing systems, which enables yeast cells to fine tune cell growth, cell cycle and their coordination in response to nutritional changes.
Year
DOI
Venue
2010
10.3390/s100606195
SENSORS
Keywords
Field
DocType
glucose sensing,yeast,cell cycle,cAMP,PKA,Rgt2/Snf3,Snf1
Glucose uptake,Biology,Biochemistry,Cell growth,Cell biology,Yeast,Signal transduction,Snf3,Saccharomyces cerevisiae,Energy source,Protein kinase A
Journal
Volume
Issue
ISSN
10
6
1424-8220
Citations 
PageRank 
References 
3
0.43
2
Authors
4
Name
Order
Citations
PageRank
Stefano Busti131.10
Paola Coccetti290.97
Lilia Alberghina3859.41
Marco Vanoni4768.30