Title | ||
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Signal abnormalities on 1.5 and 3 Tesla brain MRI in multiple sclerosis patients and healthy controls. A morphological and spatial quantitative comparison study. |
Abstract | ||
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Previous studies in patients with multiple sclerosis (MS) revealed increased lesion count and volume on 3 T compared to 1.5 T. Morphological and spatial lesion characteristics between 1.5 T and 3 T have not been examined. The aim of this study was to investigate the effect of changing from a 1.5 T to a 3 T MRI scanner on the number, volume and spatial distribution of signal abnormalities (SA) on brain MRI in a sample of MS patients and normal controls (NC), using pair- and voxel-wise comparison procedures. Forty-one (41) MS patients (32 relapsing-remitting and 9 secondary-progressive) and 38 NC were examined on both 1.5 T and 3 T within one week in random order. T2-weighted hyperintensities (T2H) and T1-weighted hypointensities (T1H) were outlined semiautomatically by two operators in a blinded fashion on 1.5 T and 3 T images. Spatial lesion distribution was assessed using T2 and T1 voxel-wise SA probability maps (SAPM). Pair-wise analysis examined the proportion of SA not simultaneously outlined on 1.5 T and 3 T. A posteriori unblinded analysis was conducted to examine the non-overlapping identifications of SA between the 1.5 T and 3 T. For pair-wise T2- and T1-analyses, a higher number and individual volume of SA were detected on 3 T compared to 1.5 T (p<0.0001) in both MS and NC. Logistic regression analysis showed that the likelihood of missing SA on 1.5 T was significantly higher for smaller SA in both MS and NC groups. SA probability map (SAPM) analysis revealed significantly more regionally distinct spatial SA differences on 3 T compared to 1.5 T in both groups (p<0.05); these were most pronounced in the occipital, periventricular and cortical regions for T2H. This study provides important information regarding morphological and spatial differences between data acquired using 1.5 T and 3 T protocols at the two scanner field strengths. |
Year | DOI | Venue |
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2009 | 10.1016/j.neuroimage.2009.04.019 | NeuroImage |
Keywords | Field | DocType |
Signal abnormalities,Field strength,Multiple sclerosis,Voxel-wise comparison | Nuclear medicine,Brain mri,Lesion,Multiple sclerosis,Psychology,Cognitive psychology,Hyperintensity,Pathology | Journal |
Volume | Issue | ISSN |
47 | 4 | 1053-8119 |
Citations | PageRank | References |
3 | 0.41 | 3 |
Authors | ||
14 |
Name | Order | Citations | PageRank |
---|---|---|---|
Carol Di Perri | 1 | 17 | 1.71 |
Michael G Dwyer | 2 | 24 | 4.05 |
David S. Wack | 3 | 10 | 2.93 |
Jennifer L. Cox | 4 | 3 | 0.41 |
Komal Hashmi | 5 | 3 | 0.41 |
Erik Saluste | 6 | 3 | 0.41 |
Sara Hussein | 7 | 10 | 1.24 |
Claudiu V. Schirda | 8 | 7 | 0.87 |
Milena Stosic | 9 | 3 | 0.41 |
Jacqueline Durfee | 10 | 7 | 0.87 |
Guy U. Poloni | 11 | 14 | 1.36 |
Navdeep Nayyar | 12 | 3 | 0.41 |
Roberto Bergamaschi | 13 | 5 | 1.17 |
Robert Zivadinov | 14 | 20 | 3.24 |