Name
Title | ||
|---|---|---|
SPOC: a widely distributed domain associated with cancer, apoptosis and transcription. |
Abstract | ||
|---|---|---|
The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level.We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods.The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality. |
Year | DOI | Venue |
|---|---|---|
2004 | 10.1186/1471-2105-5-91 | BMC Bioinformatics |
Keywords | Field | DocType |
amino acid sequence,c terminal domain,proteins,signal recognition particle,apoptosis,n terminal,conserved sequence,bioinformatics,rna recognition motif,microarrays,algorithms | RNA,Drosophila Protein,Conserved sequence,Transcription (biology),Biology,Signal recognition particle,Bioinformatics,Genetics,Cancer,DNA microarray,Peptide sequence | Journal |
Volume | Issue | ISSN |
5 | 1 | 1471-2105 |
Citations | PageRank | References |
1 | 1.25 | 5 |
Authors | ||
5 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Luis Sánchez-Pulido | 1 | 2 | 3.16 |
| Ana M Rojas | 2 | 22 | 3.40 |
| Karel H van Wely | 3 | 1 | 1.59 |
| Carlos Martinez-A | 4 | 2 | 2.12 |
| Alfonso Valencia | 5 | 2577 | 322.43 |