Name
Abstract | ||
|---|---|---|
In the pathogen P. aeruginosa, the formation of virulence factors is regulated via Quorum sensing signaling pathways. Due to the increasing number of strains that are resistant to antibiotics, there is a high interest to develop novel antiinfectives. In the combat of resistant bacteria, selective blockade of the bacterial cell–to–cell communication (Quorum sensing) has gained special interest as anti–virulence strategy. Here, we modeled the las, rhl, and pqs Quorum sensing systems by a multi–level logical approach to analyze how enzyme inhibitors and receptor antagonists effect the formation of autoinducers and virulence factors. |
Year | DOI | Venue |
|---|---|---|
2013 | 10.1186/1752-0509-7-81 | BMC systems biology |
Keywords | Field | DocType |
Quorum sensing, Multi–level logical approach, Boolean network, Gene–regulatory network, Inhibitor, Pseudomonas aeruginosa, pqs system | Autoinducer,Quorum sensing,Biology,Systems biology,Microbiology,Bacteria,Bioinformatics,Gene regulatory network,Virulence,Pathogen,Pseudomonas aeruginosa | Journal |
Volume | Issue | ISSN |
7 | 1 | 1752-0509 |
Citations | PageRank | References |
5 | 0.45 | 5 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Nadine S. Schaadt | 1 | 15 | 2.37 |
| Anke Steinbach | 2 | 5 | 0.45 |
| Rolf W Hartmann | 3 | 14 | 1.91 |
| Volkhard Helms | 4 | 78 | 10.45 |