Title
Inhibition of quorum sensing in a computational biofilm simulation.
Abstract
Bacteria communicate through small diffusible molecules in a process known as quorum sensing. Quorum-sensing inhibitors are compounds which interfere with this, providing a potential treatment for infections associated with bacterial biofilms. We present an individual-based computational model for a developing biofilm. Cells are aggregated into particles for computational efficiency, but the quorum-sensing mechanism is modelled as a stochastic process on the level of individual cells.
Year
DOI
Venue
2012
10.1016/j.biosystems.2012.02.002
Biosystems
Keywords
Field
DocType
Bacteria,Simulation,Quorum sensing,Inhibitor
Nanotechnology,Biofilm,Bistability,Quorum sensing,Biology,Positive feedback,Bacteria,Computational biology,Genetics,Virulence
Journal
Volume
Issue
ISSN
109
2
0303-2647
Citations 
PageRank 
References 
1
0.41
4
Authors
4
Name
Order
Citations
PageRank
John A. Fozard110.41
Michael Lees2513.36
King J R310.41
Logan B S410.41