Name
Abstract | ||
|---|---|---|
Purpose Prediction of progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) is challenging but essential for
early treatment. This study aims to investigate the use of hippocampal atrophy markers for the automatic detection of MCI
converters and to compare the predictive value to manually obtained hippocampal volume and temporal horn width.
Methods A study was performed with 15 patients with Alzheimer and 18 patients with MCI (ten converted, eight remained stable in a
3-year follow-up) as well as 15 healthy subjects. MRI scans were obtained at baseline and evaluated with an automated system
for scoring of hippocampal atrophy. The predictive value of the automated system was compared with manual measurements of
hippocampal volume and temporal horn width in the same subjects.
Results The conversion to AD was correctly predicted in 77.8% of the cases (sensitivity 70%, specificity 87.5%) in the MCI group using
automated morphometry and a plain linear classifier that was trained on the AD and healthy groups. Classification was improved
by limiting analysis to the left cerebral hemisphere (accuracy 83.3%, sensitivity 70%, specificity 100%). The manual linear
and volumetric approaches reached rates of 66.7% (40/100%) and 72.2% (60/87.5%), respectively.
Conclusion The automatic approach fulfills many important preconditions for clinical application. Contrary to the manual approaches,
it is not observer-dependent and reduces human resource requirements. Automated assessment may be useful for individual patient
assessment and for predicting progression to dementia. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1007/s11548-010-0412-0 | Int. J. Computer Assisted Radiology and Surgery |
Keywords | Field | DocType |
Brain atrophy, Classification, Early detection, Converter, Baseline, Imaging biomarker | Hippocampal atrophy,Early detection,Disease,Neuroscience,Imaging biomarker,Radiology,Hippocampal formation,Medicine,Pathology,Cognitive impairment | Journal |
Volume | Issue | ISSN |
5 | 6 | 1861-6429 |
Citations | PageRank | References |
0 | 0.34 | 6 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Klaus H. Fritzsche | 1 | 23 | 5.59 |
| Stieltjes Bram | 2 | 13 | 1.11 |
| Sarah Schlindwein | 3 | 0 | 0.68 |
| Thomas van Bruggen | 4 | 0 | 0.68 |
| Marco Essig | 5 | 2 | 2.09 |
| Hans-Peter Meinzer | 6 | 20 | 4.38 |