Paper Info
Title
ProSAS: a database for analyzing alternative splicing in the context of protein structures.
Abstract
Alternative splicing is known to be one of the major sources for functional diversity in higher eukaryotes. Several splicing isoforms have been characterized in the literature that play important roles in cellular processes like apoptosis or signal transduction pathways. Splicing events can often be detected on the mRNA level by large-scale cDNA or EST experiments and such data is collected and annotated in several databases. Nevertheless, the effects of splicing on the structure of a protein are largely unknown. The ProSAS (Protein Structure and Alternative Splicing) database fills this gap and provides a unified resource for analyzing effects of alternative splicing events in the context of protein structures. ProSAS comprehensively annotates and models protein structures for several Ensembl genomes as well as SwissProt entries harbouring splicing events. Alternative isoforms annotated in Ensembl or SwissProt can be analyzed on the protein structure and protein function level using an intuitive user interface that provides several features and tools for a structure-based analysis of alternative splicing events. The ProSAS database is freely accessible at http://www.bio.ifi.lmu.de/ProSAS.
Year
DOI
Venue
2008
10.1093/nar/gkm793
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
signal transduction pathway,alternative splicing,internet,protein structure,user interface,protein conformation
Genome,Gene,Biology,Ensembl,Alternative splicing,RNA splicing,Ensembl Genomes,Genetics,Molecular biology,Database,ProSAS,Protein structure
Journal
Volume
Issue
ISSN
36
Database issue
0305-1048
Citations 
PageRank 
References 
8
0.57
13
Authors
6
Name
Order
Citations
PageRank
Fabian Birzele1745.52
Robert Küffner251259.39
Franziska Meier310713.52
Florian Oefinger480.57
Christian Potthast5994.98
Ralf Zimmer626928.70