Paper Info
Title
NORINE: a database of nonribosomal peptides.
Abstract
Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs). The molecules synthesized by NRPS contain a high proportion of nonproteogenic amino acids. The primary structure of these peptides is not always linear but often more complex and may contain cycles and branchings. In recent years, NRPs attracted a lot of attention because of their biological activities and pharmacological properties (antibiotic, immunosuppressor, antitumor, etc.). However, few computational resources and tools dedicated to those peptides have been available so far. Norine is focused on NRPs and contains more than 700 entries. The database is freely accessible at http://bioinfo.lifl.fr/norine/. It provides a complete computational tool for systematic study of NRPs in numerous species, and as such, should permit to obtain a better knowledge of these metabolic products and underlying biological mechanisms, and ultimately to contribute to the redesigning of natural products in order to obtain new bioactive compounds for drug discovery.
Year
DOI
Venue
2008
10.1093/nar/gkm792
NUCLEIC ACIDS RESEARCH
Keywords
Field
DocType
protein complex,nucleic,drug discovery,internet,amino acid,biological activity
Drug discovery,Biology,Biochemistry,Peptide,Protein primary structure,Peptide Synthases,Database,Nonribosomal peptide
Journal
Volume
Issue
ISSN
36
Database issue
0305-1048
Citations 
PageRank 
References 
20
1.41
5
Authors
6
Name
Order
Citations
PageRank
Ségolène Caboche1999.55
Maude Pupin21076.99
Valérie Leclère3303.32
Arnaud Fontaine4313.01
Philippe Jacques5272.58
Gregory Kucherov6100374.54