Name
Abstract | ||
|---|---|---|
SPRINT is a software package that performs computational multistate protein design using state-of-the-art inference on probabilistic graphical models. The input to SPRINT is a list of protein structures, the rotamers modeled for each structure and the pre-calculated rotamer energies. Probabilistic inference is performed using the belief propagation or A* algorithms, and dead-end elimination can be applied as pre-processing. The output can either be a list of amino acid sequences simultaneously compatible with these structures, or probabilistic amino acid profiles compatible with the structures. In addition, higher order ( e. g. pairwise) amino acid probabilities can also be predicted. Finally, SPRINT also has a module for protein side-chain prediction and single-state design. |
Year | DOI | Venue |
|---|---|---|
2010 | 10.1093/bioinformatics/btq445 | BIOINFORMATICS |
Keywords | Field | DocType |
predictive inference,protein design | Pairwise comparison,Source code,Inference,Computer science,Protein design,Probabilistic logic,Bioinformatics,Graphical model,Sprint,Belief propagation | Journal |
Volume | Issue | ISSN |
26 | 19 | 1367-4803 |
Citations | PageRank | References |
4 | 0.52 | 3 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Menachem Fromer | 1 | 143 | 10.47 |
| Chen Yanover | 2 | 391 | 30.06 |
| Amir Harel | 3 | 75 | 4.95 |
| Ori Shachar | 4 | 4 | 0.52 |
| Yair Weiss | 5 | 10240 | 834.60 |
| Michal Linial | 6 | 1502 | 149.92 |