Name
Title | ||
|---|---|---|
Single-trial discrimination for integrating simultaneous EEG and fMRI: Identifying cortical areas contributing to trial-to-trial variability in the auditory oddball task. |
Abstract | ||
|---|---|---|
The auditory oddball task is a well-studied stimulus paradigm used to investigate the neural correlates of simple target detection. It elicits several classic event-related potentials (ERPs), the most prominent being the P300 which is seen as a neural correlate of subjects' detection of rare (target) stimuli. Though trial-averaging is typically used to identify and characterize such ERPs, their latency and amplitude can vary on a trial-to-trial basis reflecting variability in the underlying neural information processing. Here we simultaneously recorded EEG and fMRI during an auditory oddball task and identified cortical areas correlated with the trial-to-trial variability of task-discriminating EEG components. Unique to our approach is a linear multivariate method for identifying task-discriminating components within specific stimulus- or response-locked time windows. We find fMRI activations indicative of distinct processes that contribute to the single-trial variability during target detection. These regions are different from those found using standard, including trial-averaged, regressors. Of particular note is the strong activation of the lateral occipital complex (LOC). The LOC was not seen when using traditional event-related regressors. Though LOC is typically associated with visual/spatial attention, its activation in an auditory oddball task, where attention can wax and wane from trial to trial, indicates that it may be part of a more general attention network involved in allocating resources for target detection and decision making. Our results show that trial-to-trial variability in EEG components, acquired simultaneously with fMRI, can yield task-relevant BOLD activations that are otherwise unobservable using traditional fMRI analysis. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1016/j.neuroimage.2009.03.062 | NeuroImage |
Keywords | Field | DocType |
Simultaneous EEG and fMRI,Single-trial analysis,Discriminating component,Auditory oddball,P300,Target detection | Brain mapping,Neural correlates of consciousness,Neuroscience,Information processing,Linear model,Cognitive psychology,Psychology,Oddball paradigm,Speech recognition,Stimulus (physiology),EEG-fMRI,Electroencephalography | Journal |
Volume | Issue | ISSN |
47 | 1 | 1053-8119 |
Citations | PageRank | References |
21 | 1.26 | 13 |
Authors | ||
7 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Robin I. Goldman | 1 | 103 | 8.75 |
| Cheng-Yu Wei | 2 | 21 | 1.26 |
| Marios G. Philiastides | 3 | 60 | 4.92 |
| Adam D. Gerson | 4 | 227 | 22.31 |
| David Friedman | 5 | 21 | 1.26 |
| Truman R. Brown | 6 | 92 | 10.77 |
| Paul Sajda | 7 | 651 | 89.86 |