Name
Title | ||
|---|---|---|
Irregular firing of isolated cortical interneurons in vitro driven by intrinsic stochastic mechanisms. |
Abstract | ||
|---|---|---|
Pharmacologically isolated GABAergic irregular spiking and stuttering interneurons in the mouse visual cortex display highly irregular spike times, with high coefficients of variation approximately 0.9-3, in response to a depolarizing, constant current input. This is in marked contrast to cortical pyramidal cells, which spike quite regularly in response to the same current injection. We applied time-series analysis methods to show that the irregular behavior of the interneurons was not a consequence of low-dimensional, deterministic processes. These methods were also applied to the Hindmarsh and Rose neuronal model to confirm that the methods are adequate for the types of data under investigation. This result has important consequences for the origin of fluctuations observed in the cortex in vivo. |
Year | DOI | Venue |
|---|---|---|
2008 | 10.1162/neco.2008.20.1.44 | Neural Computation |
Keywords | Field | DocType |
irregular spike time,gabaergic irregular spiking,irregular firing,intrinsic stochastic mechanism,isolated cortical interneurons,high coefficient,deterministic process,mouse visual cortex display,rose neuronal model,irregular behavior,stuttering interneurons,constant current input,current injection,time series analysis,coefficient of variation | Cortex (botany),Neuroscience,GABAergic,Cortical Synchronization,Neurotransmission,Visual cortex,Neural Inhibition,Depolarization,Interneuron,Mathematics | Journal |
Volume | Issue | ISSN |
20 | 1 | 0899-7667 |
Citations | PageRank | References |
2 | 0.47 | 3 |
Authors | ||
3 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Bernhard Englitz | 1 | 2 | 0.81 |
| Klaus M. Stiefel | 2 | 44 | 5.82 |
| Terrence J. Sejnowski | 3 | 8278 | 2135.10 |