Name
Title | ||
|---|---|---|
Probe design optimization of HLA microarray: Data cleaning of probe signals from cDNA tiling microarray: Outlier detection, noise reduction, and identification of uninformative probes in HLA typing application |
Abstract | ||
|---|---|---|
Custom made tiling cDNA microarrays have been developed for high resolution HLA genotyping. The array comprises tens of thousands of sequence-specific oligonucleotide probes (SSOP) that hybridize with HLA sequences. Sophisticated methods for analyzing the multidimensional complex data are needed due to large amounts of data generated from the microarray experiments. Moreover, the inconsistencies, noise, and outliers in the probe signals add additional complexities. We proposed data cleaning methods for the identification of uninformative and misinformative probes to improve the performance of HLA typing process. |
Year | DOI | Venue |
|---|---|---|
2011 | 10.1109/BIBMW.2011.6112452 | BIBM Workshops |
Keywords | Field | DocType |
hla typing application,hla sequence,high resolution,multidimensional complex data,large amount,hla microarray,probe signal,microarray experiment,cdna tiling microarray,additional complexity,cdna microarrays,hla typing process,misinformative probe,probe design optimization,hla genotyping,data cleaning,complex data,noise reduction,microarray data,outlier detection,proteins,oligonucleotide probe,lab on a chip,hla typing,genomics | Noise reduction,Anomaly detection,Genotyping,Microarray,Computer science,Outlier,Microarray analysis techniques,Oligonucleotide,Human leukocyte antigen,Bioinformatics | Conference |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Esma Dilek | 1 | 0 | 0.34 |
| Tanya Zlateva | 2 | 12 | 1.56 |
| G.L. Zhang | 3 | 208 | 16.91 |
| Lou Chitkushev | 4 | 31 | 9.07 |
| Jaeyoung Lee | 5 | 454 | 102.07 |
| Vladimir Brusic | 6 | 551 | 63.37 |