Paper Info
Title
Symmetric abnormalities in sulcal patterning in schizophrenia.
Abstract
To compare the morphology of the cerebral cortex and its characteristic pattern of gyri and sulci in individuals with and without schizophrenia, T1-weighted magnetic resonance scans were collected, along with clinical and cognitive information, from 33 individuals with schizophrenia and 30 healthy individuals group-matched for age, gender, race and parental socioeconomic status. Sulcal depth was measured across the entire cerebral cortex by reconstructing surfaces of cortical mid-thickness (layer 4) in each hemisphere and registering them to the human PALS cortical atlas. Group differences in sulcal depth were tested using methods for cluster size analysis and interhemispheric symmetry analysis. A significant group difference was found bilaterally in the parietal operculum, where the average sulcal depth was shallower in individuals with schizophrenia. In addition, group differences in sulcal depth showed significant bilateral symmetry across much of the occipital, parietal, and temporal cortices. In individuals with schizophrenia, sulcal depth in the left hemisphere was correlated with the severity of impaired performance on tests of working memory and executive function.
Year
DOI
Venue
2008
10.1016/j.neuroimage.2008.07.034
NeuroImage
Keywords
Field
DocType
working memory,left hemisphere,magnetic resonance imaging,brain mapping,schizophrenia,socioeconomic status,magnetic resonance
Brain mapping,Bilateral symmetry,Developmental psychology,Lateralization of brain function,Working memory,Psychology,Cognitive psychology,Cerebral cortex,Cognition,Schizophrenia,Magnetic resonance imaging
Journal
Volume
Issue
ISSN
43
3
1053-8119
Citations 
PageRank 
References 
8
0.56
5
Authors
7
Name
Order
Citations
PageRank
John G Csernansky158835.28
Sarah K. Gillespie2372.71
Donna L. Dierker3573.94
Alan Anticevic41338.22
Lei Wang520124.38
Deanna M. Barch6118751.86
D VANESSEN713310.39