Title
Multi-class sparse Bayesian regression for neuroimaging data analysis
Abstract
The use of machine learning tools is gaining popularity in neuroimaging, as it provides a sensitive assessment of the information conveyed by brain images. In particular, finding regions of the brain whose functional signal reliably predicts some behavioral information makes it possible to better understand how this information is encoded or processed in the brain. However, such a prediction is performed through regression or classification algorithms that suffer from the curse of dimensionality, because a huge number of features (i.e. voxels) are available to fit some target, with very few samples (i.e. scans) to learn the informative regions. A commonly used solution is to regularize the weights of the parametric prediction function. However, model specification needs a careful design to balance adaptiveness and sparsity. In this paper, we introduce a novel method, Multi-Class Sparse Bayesian Regression (MCBR), that generalizes classical approaches such as Ridge regression and Automatic Relevance Determination. Our approach is based on a grouping of the features into several classes, where each class is regularized with specific parameters. We apply our algorithm to the prediction of a behavioral variable from brain activation images. The method presented here achieves similar prediction accuracies than reference methods, and yields more interpretable feature loadings.
Year
DOI
Venue
2010
10.1007/978-3-642-15948-0_7
MLMI
Keywords
Field
DocType
automatic relevance determination,ridge regression,novel method,similar prediction accuracy,parametric prediction function,neuroimaging data analysis,behavioral information,brain image,brain activation image,behavioral variable,reference method,brain imaging,machine learning,data analysis,model specification,curse of dimensionality
Voxel,Pattern recognition,Regression,Computer science,Bayesian linear regression,Curse of dimensionality,Parametric statistics,Artificial intelligence,Relevance vector machine,Specification,Statistical classification,Machine learning
Conference
Volume
ISSN
ISBN
6357
0302-9743
3-642-15947-8
Citations 
PageRank 
References 
3
0.44
8
Authors
4
Name
Order
Citations
PageRank
Vincent Michel14056181.15
Evelyn Eger216424.65
Christine Keribin36516.14
Bertrand Thirion45047270.40