Name
Abstract | ||
|---|---|---|
Boundary value formulations are presented for exact and efficient sensitivity analysis, with respect to model parameters and initial conditions, of different classes of oscillating systems. Methods for the computation of sensitivities of derived quantities of oscillations such as period, amplitude, and different types of phases are first developed for limit-cycle oscillators. In particular, a novel decomposition of the state sensitivities into three parts is proposed to provide an intuitive classification of the influence of parameter changes on period, amplitude, and relative phase. The importance of the choice of time reference, i.e., the phase locking condition, is demonstrated and discussed, and its influence on the sensitivity solution is quantified. The methods are then extended to other classes of oscillatory systems in a general formulation. Numerical techniques are presented to facilitate the solution of the boundary value problem and the computation of different types of sensitivities. Numerical results are verified by demonstrating consistency with finite difference approximations and are superior both in computational efficiency and in numerical precision to existing partial methods. |
Year | DOI | Venue |
|---|---|---|
2009 | 10.1137/070707129 | SIAM J. Scientific Computing |
Keywords | Field | DocType |
sensitivity analysis,biomedical research,boundary value problem,dynamic system,oscillations,limit cycle,bioinformatics | Boundary value problem,Mathematical analysis,Finite difference,Limit cycle,Dynamical systems theory,Finite difference method,Initial value problem,Numerical analysis,Partial differential equation,Mathematics | Journal |
Volume | Issue | ISSN |
31 | 4 | 1064-8275 |
Citations | PageRank | References |
13 | 1.28 | 4 |
Authors | ||
4 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| A. Katharina Wilkins | 1 | 15 | 1.94 |
| Bruce Tidor | 2 | 112 | 15.30 |
| Jacob White | 3 | 285 | 39.12 |
| Paul I. Barton | 4 | 706 | 61.90 |