Paper Info
Title
Discovering gene association networks by multi-objective evolutionary quantitative association rules
Abstract
In the last decade, the interest in microarray technology has exponentially increased due to its ability to monitor the expression of thousands of genes simultaneously. The reconstruction of gene association networks from gene expression profiles is a relevant task and several statistical techniques have been proposed to build them. The problem lies in the process to discover which genes are more relevant and to identify the direct regulatory relationships among them. We developed a multi-objective evolutionary algorithm for mining quantitative association rules to deal with this problem. We applied our methodology named GarNet to a well-known microarray data of yeast cell cycle. The performance analysis of GarNet was organized in three steps similarly to the study performed by Gallo et al. GarNet outperformed the benchmark methods in most cases in terms of quality metrics of the networks, such as accuracy and precision, which were measured using YeastNet database as true network. Furthermore, the results were consistent with previous biological knowledge.
Year
DOI
Venue
2014
10.1016/j.jcss.2013.03.010
J. Comput. Syst. Sci.
Keywords
Field
DocType
discovering gene association network,multi-objective evolutionary quantitative association,relevant task,gene expression profile,microarray technology,direct regulatory relationship,well-known microarray data,quantitative association rule,gene association network,last decade,benchmark method,yeastnet database,microarray analysis,data mining,gene networks
Data mining,Gene,Evolutionary algorithm,Association rule learning,Microarray analysis techniques,Gene chip analysis,Gene regulatory network,Mathematics
Journal
Volume
Issue
ISSN
80
1
0022-0000
Citations 
PageRank 
References 
12
0.49
49
Authors
3
Name
Order
Citations
PageRank
M. Martínez-Ballesteros1937.57
I. A. Nepomuceno-Chamorro2120.49
J. C. Riquelme323914.01