Name
Abstract | ||
|---|---|---|
Transcription factors with a large number of target genes - transcription hub( s), or THub( s) - are usually crucial components of the regulatory system of a cell, and the different patterns through which they transfer the transcriptional signal to downstream cascades are of great interest. By profiling normalized abundances ( AN) of basic regulatory patterns of individual THubs in the yeast Saccharomyces cerevisiae transcriptional regulation network under five different cellular states and environmental conditions, we have investigated their preferences for different basic regulatory patterns. Subgraph-normalized abundances downstream of individual THubs often differ significantly from that of the network as a whole, and conversely, certain over-represented subgraphs are not preferred by any THub. The THub preferences changed substantially when the cellular or environmental conditions changed. This switching of regulatory pattern preferences suggests that a change in conditions does not only elicit a change in response by the regulatory network, but also a change in the mechanisms by which the response is mediated. The THub subgraph preference profile thus provides a novel tool for description of the structure and organization between the large- scale exponents and local regulatory patterns. |
Year | DOI | Venue |
|---|---|---|
2006 | 10.1371/journal.pcbi.0020047 | PLOS COMPUTATIONAL BIOLOGY |
Keywords | Field | DocType |
gene transcription,transcription factors,transcription factor,transcription regulation,cell cycle | Transcriptional regulation,Gene targeting,Transcription (biology),Biology,Regulation of gene expression,Bioinformatics,Saccharomyces cerevisiae,Gene regulatory network,Genetics,Transcription factor | Journal |
Volume | Issue | ISSN |
2 | 5 | 1553-734X |
Citations | PageRank | References |
5 | 0.45 | 3 |
Authors | ||
11 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zhihua Zhang | 1 | 198 | 45.87 |
| Changning Liu | 2 | 183 | 15.24 |
| Geir Skogerbø | 3 | 186 | 13.94 |
| Xiaopeng Zhu | 4 | 79 | 5.85 |
| Hongchao Lu | 5 | 58 | 3.73 |
| Lan Chen | 6 | 21 | 2.25 |
| Baochen Shi | 7 | 52 | 2.93 |
| Yong Zhang | 8 | 139 | 13.89 |
| Jie Wang | 9 | 63 | 4.07 |
| Tao Wu | 10 | 23 | 2.29 |
| Runsheng Chen | 11 | 404 | 31.48 |