Paper Info
Title
Antimic: A Database Of Antimicrobial Sequences
Abstract
Antimicrobial peptides (AMPs) are important components of the innate immune system of many species. These peptides are found in eukaryotes, including mammals, amphibians, insects and plants, as well as in prokaryotes. Other than having pathogen-lytic properties, these peptides have other activities like antitumor activity, mitogen activity, or they may act as signaling molecules. Their short length, fast and efficient action against microbes and low toxicity to mammals have made them potential candidates as peptide drugs. In many cases they are effective against pathogens that are resistant to conventional antibiotics. They can serve as natural templates for the design of novel antimicrobial drugs. Although there are vast amounts of data on natural AMPs, they are not available through one central resource. We have developed a comprehensive database (ANTIMIC, http://research.i2r.a-star.edu.sg/Templar/DB/ANTIMIC/) of known and putative AMPs, which contains similar to1700 of these peptides. The database is integrated with tools to facilitate efficient extraction of data and their analysis at molecular level, as well as search for new AMPs. These tools include BLAST, PDB structure viewer and the Antimic profile module.
Year
DOI
Venue
2004
10.1093/nar/gkh032
NUCLEIC ACIDS RESEARCH
Keywords
DocType
Volume
computational biology,innate immune system,internet
Journal
32
Issue
ISSN
Citations 
Database issue
0305-1048
17
PageRank 
References 
Authors
2.71
4
8
Name
Order
Citations
PageRank
M Brahmachary1172.71
S. P. T. Krishnan2695.44
J L Koh311014.39
Asif M. Khan417611.19
S H Seah57910.51
Tin Wee Tan656636.14
Vladimir Brusic755163.37
Vladimir B. Bajic832133.71